Early clinical studies suggest that reducing sugary beverages and total fructose intake, especially from added sugars, may have a significant benefit on reducing hepatic fat accumulation.
Investigators provided substantial support to help the subjects achieve this goal. Hepatic lipase activity was assayed spectrophotometrically using p-nitrophenyl palmitate p-NPP as substrate according to the method of Krieger et al.
The first group HFS was left untreated; this was the positive control group. Fructose increases hepatic de novo lipogenesis in a dose-dependent fashion and de novo lipogenesis has been shown to be abnormally unregulated in patients with NAFLD.
Diabetes occurs when your body is no longer able to effectively regulate blood sugar levels. The electron microscopy study also revealed hepatocytes with abundant lipid droplets in the HFS-fed rats Fig.
Condition or disease. The current prescription for children with NAFLD—exercise, calorie restriction, and weight loss—is inconsistently effective for various reasons including compliance challenges. Many scientists believe that excess fructose consumption may be a key driver of many of the most serious diseases of today.